The San Pancrazio Gate stands at the highest point of the Janikulum Hill. Its construction together with the surrounding walls was commissioned by Pope Urban VIII. Her current appearance is the work of the Italian architect Virginio Vespignani. The artist's pride is the emblems of Pope Pius IX and Urban VIII, stylized for the 18th century. Currently, the building is the seat of the Museum of the Roman Republic and the Garibaldim Memorial.
In 1849 there was a decisive battle between the French army and Garibaldi. The French were unable to conquer the San Pancrazio gate and eventually managed to enter Rome breaking the walls near Villa Sciarra. However, the gate was almost completely destroyed. In 1854, Vespignani reconstructed the object.
This gate was known as Porta Aurelia, as it was the beginning of Via Aurelii. The building owes its present name to the vicinity of the Basilica of San Pancrazio.