The Madrid chapel of Our Lady and Saint John Lateran is also called the chapel of Bishop Plasencia, who was the initiator of its construction. The building belongs to the transition period between the Gothic style of its architectural layout and the Renaissance art visible in its northern facade and in interior decoration.
The chapel was built in the 16th century and is part of the larger St. Andrew's parish complex, which includes the Gothic church of St. Andrew and the chapel of St. Izydor erected in the baroque style. This monumental temple complex covers almost the entire quarter of streets. The chapel of the Mother of God and St. John Lateran was built in the place of an earlier chapel.
The chapel of Bishop Placencia was erected to contain the remains of St. Isidore. It is a response to the initiative of Francisco de Vargas, one of the most powerful medieval Madrid, for whom the saint worked in the family in the 12th century. In the following centuries, a powerful complex of the parish of St. Andrew.